De Leon is a city located in Comanche County in the U.S. state of Texas. The population was 2,246 at the time of the 2010 census. It is commonly associated with being named after the Spanish explorer Ponce de Leon; however the town actually obtains its name due to the location of the Leon River, translates to de Leon in Spanish, which flows directly North and East of the community, and drains into nearby Lake Proctor.